President's Office

President's Remarks | Curriculum Vitae | Research | Publication | Members

Kenneth K. Wu, M.D., Ph.D.

Curriculum Vitae

Education

1995-1997 University of London, United Kingdom: Ph.D.
1967-1968 Yale University School of Medicine, New Haven, CT: M.S.
1959-1966 National Taiwan University Medical School, Taipei, Taiwan: M.D.

Residency and Fellowship

1971-1973 Fellowship (NIH) in Hematology/Oncology, University of Iowa, Iowa City, IA
1970-1971 Residency in Medicine, University of Iowa, Iowa City, IA
1969-1970 Residency in Obstetrics and Gynecology, Barnes Hospital, Washington University, St. Louis and in Medicine, St. Lukes' Hospital, St. Louis, MO
1968-1969 Internship in Medicine, Bridgeport Hospital, Bridgeport CT

Academic Appointments

1997-2006 Consultant and Adjunct Professor, Professor, Department of Blood and Marrow Transplantation, Division of Cancer Medicine, University of Texas, M.D. Anderson Cancer Center
2001-2006 Associate Director, Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center
1997-1999 Distinguished Fellow and Director, Institute of Biomedical Sciences, Academia Sinica, Taipei,Taiwan
1992-2006 Roy M. and Phyllis Gough Huffington Professor in Gerontology, University of Texas-Houston Health Science Center
1991-1992 Visiting Professor, The William Harvey Research Institute, St. Bartholomew's Hospital Medical College, London, England
1983-2006 Professor of Medicine, Director of Division of Hematology and Oncology, Professor of Pathology and Laboratory Medicine, Director of General Clinical Research Center, Director of Vascular Biology Research Center, Vice Chairman of Department of Medicine, University of Texas Medical School at Houston, Houston, TX
1984-2006 Adjunct Professor, Biomedical Research Laboratory, Rice University, Houston, TX
1976-1983 Associate Professor, Professor of Medicine, Director Coagulation and Thrombosis Unit, Rush Medical College, Chicago, IL
1973-1976 Associate in Medicine, Assistant Professor of Medicine, University of Iowa, Iowa City, IA

Hospital Appointments

1997-2006 M.D. Anderson Cancer Center, Houston, TX
1989-2006 Lyndon B. Johnson General Hospital, Houston, TX
1983-2006 Memorial Hermann Hospital, Houston, TX
1976-1983 Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL
1973-1976 University of Iowa Hospitals, Iowa City, IA
1973-1976 Veterans Administration Hospital, Iowa City, IA

Honors and Awards

2004 Thomson ISI top-ten most cited author in the last decade
2000 University of Texas-Houston Health Science Center President's Scholar Award
1997 Elected to membership of American Association of Physicians
1997 SANOFI Prize, SANOFI Association for Thrombosis Research and International Society of Thrombosis and Haemostasis
1994 Proclamation of December 9, as Kenneth K. Wu, M.D. Day by Mayor Lanier of Houston
1994 Academician (Member), Academia Sinica (National Academy of Science, Taiwan)
1985 Outstanding Alumni Award Lectureship, National Taiwan University Medical College, 40th Anniversary, Taipei, Taiwan
1982 Elected to membership of American Society of Clinical Investigation

Editorial Boards

2004-Present Editorial Board, Current Cardiology Review
2003-Present Associate Editor, Prostaglandins and Other Lipid Mediators
2001-Present Editorial Board, Arteriosclerosis, Thrombosis and Vascular Biology
1996-2004 Associate Editor, Circulation
1994-2002 Editorial Board, Tissue Engineering
1993-Present Editorial Board, Journal of Biomedical Science
1993-1995 Editorial Board, Circulation
1986-1991 Editorial Board, Prostaglandins
1987-1990 Editorial Board, Eicosanoids

Research Fields of Interest

Mediators of Arterial Thrombosis
Molecular Biology and Biochemistry of Cyclooxygenase and Nitric Oxide Synthase

Publication

Original Articles | Review Articles and Book Chapters | Books

Selected Original Articles in Referenced Journals (from 1991)

01. Deng, W.G., Tang, S.T., Tseng, H.P., Wu, K.K. Melatonin suppresses macrophage cyclooxygenase-2 and inducible nitric oxide synthase expression by inhibiting p52 acetylation and binding. Blood. 2006 Apr 11; [Epub ahead of print]
02. Liou, J.Y., Lee, S., Ghelani, D., Matijevic-Aleksic, N., Wu, K.K. Protection of endothelial survival by peroxisome proliferator-activated receptor-{delta} mediated 14-3-3 upregulation. Arterioscler. Thromb. Vasc. Biol. 2006 Apr 27; [Epub ahead of print]
03. Lin, T.N., Cheung, W.M., Wu, J.S., Chen, J.J., Lin, H., Chen, J.J., Liou, J.Y., Shyue, S.K., Wu, K.K. 15d-Prostaglandin J2 Protects Brain From Ischemia-Reperfusion Injury. Arterioscler. Thromb. Vasc. Biol. 26:481-487, 2006.
04. Liou, J.Y., Aleksic, N., Chen, S.F., Han, T.J., Shyue, S.K., Wu, K.K. Mitochondrial localization of cyclooxygenase-2 and calcium-independent phospholipase A2 in human cancer cells: implication in apoptosis resistance. Exp. Cell Res. 306:75-84, 2005.
05. Cieslik, K., Zhu, Y., Shtivelband, M., Wu, K.K. Inhibition of p90 ribosomal S6 kinase-mediated C/EBPbeta activation and COX-2 expression by salicylate. J. Biol. Chem., 280: 18411-18417, 2005.
06. Gibson, L.L., Hahner, L., Osborne-Lawrence, S., German, Z., Wu, K.K., Chambliss, K.L., Shaul, P.W. Molecular basis of estrogen-induced cyclooxygenase type 1 upregulation in endothelial cells. Circ. Res., 96: 518-525, 2005.
07. Huang, J-C., Wun, W-S.A., Goldsby, J.S., Matijevic-Aleksic, N., Wu, K.K. Cyclooxygenase-2-derived endogenous prostacyclin enhances mouse embryo hatching. Hum. Reprod. 19:2900-2906, 2004.
08. Huang, J-C., Goldsby, J.S., Arbab, F., Melhem, Z., Aleksic, N., Wu, K.K. Oviduct prostacyclin functions as a paracrine factor to augment the development of embryos. Hum. Reprod. 19: 2907-2912, 2004.
09. Yu, I-S., Lin, S-R., Huang, C-C., Tseng, H-Y., Huang, P-H., Shi, G-Y., Wu, H-L., Tang, C-L., Chu, P-H., Wang, L-H., Wu, K.K., Lin, S-W. TXAS-deleted mice exhibit normal thrombopoiesis, defective hemostasis and resistance to arachidonate-induced death. Blood, 104: 135-142, 2004.
10. Deng, W-G., Zhu, Y., Wu, K.K. Role of p300 and PCAF in regulating cyclooxygenase-2 promoter activation by inflammatory mediators. Blood, 103: 2135-2142, 2004.
11. Afshar-Kharghan, V., Matijevic-Aleksic, N., Ahn, C., Boerwinkle, E., Wu, K.K., Lopez, J.A. The variable number of tandem repeat polymorphism of platelet glycoprotein Ibα and risk of coronary heart disease. Blood, 103: 963-965, 2004.
12. Delgado, R.M. 3rd, Nawar, M.A., Zewail, A.M., Kar, B., Vaughn, W.K., Wu, K.K., Aleksic, N., Sivasubramanian, N., McKay, K., Mann, D.L., Willerson, J.T. Cyclooxygenase-2 inhibitor treatment improves left ventricular function and mortality in a murine model of doxorubicin-induced heart failure. Circulation, 109: 1428-1433, 2004.
13. Deng, W-G., Zhu, Y., Montero, A., Wu, K.K. Quantitative analysis of binding of transcription factor complex to biotinylated DNA probe by a streptavidin-agarose pulldown assay. Anal. Biochem. 323: 12-18, 2003.
14. Deng, W-G., Wu, K.K. Regulation of inducible nitric oxide synthase expression by p300 and p50 acetylation. J. Immunology, 171: 6581-6588, 2003.
15. Huang, J.C., Wun, W.S.A., Goldsby, J.S., Wun, I.C., Falconi, S.M., Wu, K.K. Prostacyclin enhances embryo hatching but not sperm motility. Hum. Reprod., 18: 2582-2589, 2003.
16. Wu, K.K., Aleksic, N., Ballantyne, C.M., Ahn, C., Juneja, H., Boerwinkle, E. Interaction between soluble thrombomodulin and intercellular adhesion molecule-1 in predicting risk of coronary heart disease. Circulation, 107:1729-1732, 2003.
17. Chen, P-F., Berka, V., Wu, K.K. Differential effects of mutations in human endothelial nitric oxide synthase at residues Tyr-357 and Arg-365 on L-arginine hydroxylation and GN-hydroxy-L-arginine oxidation. Arch. Biochem. Biophys., 411: 83-92, 2003.
18. Deng, W-G., Zhu, Y., Wu, K.K. Upregulation of p300 binding and p50 acetylation in tumor necrosis factor-α induced cyclooxygenase-2 promoter activation.J. Biol. Chem., 278: 4770-4777, 2003.
19. Cieslik, K., Zhu, Y., Wu, K.K.Salicylate suppresses macrophage nitric oxide synthase-2 and cyclooxygenase-2 expression by inhibiting C/EBPβ-binding via a common signaling pathway. J. Biol. Chem., 277: 49304-49310, 2002.
20. Huang, J.C., Arbab, F., Tumbusch, K.J., Goldsby, J.S., Matijevic-Aleksic, N., Wu, K.K. Human Fallopian Tubes Express Prostacyclin (PGI) Synthase and Cyclooxygenases and Synthesize Abundant PGI. J. Clin. Endocrinol. Metab., 87: 4361-4368, 2002.
21. Deng, W., Saunders, M.A., Gilroy, D.W., He, X-Z., Yeh, H., Zhu, Y., Shtivelband, M.I., Ruan, K-H., Wu, K.K. Purification and characterization of a cyclooxygenase-2 and angiogenesis suppressing factor produced by human fibroblasts. FASEB J., 16: 1286-1288, 2002.
22. Schroer, K., Zhu, Y., Saunders, M.A., Deng, W-G., Xu, X-M., Meyer-Kirchrath, J., Wu, K.K. The obligatory role of cyclic AMP response element in cyclooxygenase-2 promoter induction and feedback regulation by inflammatory mediators. Circulation, 105: 2760-2765, 2002.
23. Scott, B.T., Hasstedt, S.J., Bovill, E.G., Callas, P.W., Valliere, J.E., Wang, L., Wu, K.K., Long, G.L. Characterization of the human prostaglandin H synthase 1 gene (PTGS1): exclusion by genetic linkage analysis as a second modifier gene in familial thrombosis. Blood Coagulation and Fibrinolysis, 13: 519-531, 2002.
24. Lin, H., Lin, T-N., Cheung, W-M., Nian, G-M., Tseng, P-H., Chen, S-F., Chen, J-J., Shyue, S?K., Liou, J-Y., Wu, C-W., Wu, K.K. Cyclooxygenase-1 (COX-1) and bicistronic COX-1/prostacyclin synthase gene transfer protect against ischemic cerebral infarction. Circulation, 105: 1962-1969, 2002.
25. Zhu, Y., Saunders, M.A., Yeh, H., Deng, W-G., Wu, K.K. Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer binding proteins. J. Biol. Chem., 277: 6923-6928, 2002.
26. Deng, W-G., Ruan, K-H., Du, M., Saunders, M.A., Wu, K.K. Aspirin and salicylate bind to immunoglobulin heavy chain binding protein (BiP) and inhibits its ATPase activity in human fibroblasts. FASEB J., 15: 2463-2470, 2001.
27. Juan, S-H., Lee, T-S., Tseng, K-W., Liou, J-Y., Shyue, S-K., Wu, K.K., Chau, L-Y. Adenovirus-mediated heme oxygenase-1 gene transfer inhibits the development of atherosclerosis in apolipoprotein E-deficient mice. Circulation, 104: 1519-1525, 2001.
28. Liou, J.Y., Deng, W.G., Gilroy, D.W., Shyue, S.K., Wu, K.K. Colocalization and Interaction of Cyclooxygenase-2 with Caveolin-1 in Human Fibroblasts. J. Biol. Chem., 276: 34975-34982, 2001.
29. Gilroy, D.W., Saunders, M.A., Wu, K.K. COX-2 expression and cell cycle progression in human fibroblasts. Am. J. Physiol. Cell Physiol., 281: C188-194, 2001.
30. Saunders, M.A., Sansores-Garcia, L., Gilroy, D.W., Wu, K.K. Selective suppression of CCAAT/enhancer-binding protein beta binding and cyclooxygenase-2 promoter activity by sodium salicylate in quiescent human fibroblasts. J. Biol. Chem., 276: 18897-18904, 2001.
31. Shyue, S.K., Tsai, M.J., Liou, J.Y., Willerson, J.T., Wu, K.K. Selective Augmentation of Prostacyclin Production by Combined Prostacyclin Synthase and Cyclooxygenase-1 Gene Transfer. Circulation, 103: 2090-2095, 2001.
32. Cieslik, K., Abrams, C.S., Wu, K.K. Up-regulation of endothelial nitric-oxide synthase promoter by the phosphatidylinositol 3-kinase gamma/Janus kinase 2/MEK-1-dependent pathway. J. Biol. Chem., 276: 1211-1219, 2001.
33. Gilroy, D.W., Saunders, M.A., Sansores-Garcia, L., Matijevic-Aleksic, N., Wu, K.K. Cell cycle-dependent expression of cyclooxygenase-2 in human fibroblasts. FASEB J. 15: 288-290, 2001.
34. Gilroy, D.W., Saunders, M.A., Wu, K.K. COX-2 expression and cell-cycle progression in human fibroblasts. Am. J. Physiol. Cell Physiol. 281:C188-C194, 2001.
35. Wu, K.K., Aleksic, N., Ahn, C., Boerwinkle, E., Folsom, A.R., Juneja, H.S. Thrombomodulin ALA 455 VAL polymorphism and risk of coronary heart disease. Circulation, 103: 1386-1389, 2001.
36. McCormick, S.M., Whitson, P.A., Wu, K.K., McIntire, L.V. Shear stress differentially regulates PGHS-1 and PGHS-2 protein levels in human endothelial cells. Ann. Biomed. Eng., 28: 824-833, 2000.
37. Aleksic, N., Juneja, H., Folsom, A.R., Ahn, C., Boerwinkle, E., Chambless, L.E., Wu, K.K. Platelet PLA2 allele and incidence of coronary heart disease: results from the Atherosclerosis Risk In Communities (ARIC) Study. Circulation, 102: 1901-1905, 2000.
38. Liou, J-Y. Shyue, S-K., Tsai, M.J., Chung, C.L., Chu, K.Y., Wu, K.K. Colocalization of prostacyclin synthase with prostaglandin H synthase-1 (PGHS-1) but not phorbol ester-induced PGHS-2 in cultured endothelial cells. J. Biol. Chem., 275: 15314-15320, 2000.
39. Chen, P-F., Wu, K.K. Characterization of the roles of the 594-645 region in human endothelial nitric-oxide synthase in regulating calmodulin binding and electron transfer. J. Biol. Chem., 275: 13155-13163, 2000.
40. Cieslik, K., Lee, C-M., Tang, J-L., Wu, K.K. Transcriptional regulation of endothelial nitric-oxide synthase by an interaction between casein kinase 2 and protein phosphatase 2A. J. Biol. Chem., 274: 34669-34675, 1999.
41. Godbey, W.T., Wu, K.K., Hirasaki, G.J., Mikos, A.G. Improved packing of poly(ethyleninmine)/DNA complexes increases transfection efficiency. Gene Therapy, 6: 1380-1388, 1999.
42. Folsom, A.R., Rosamond, W.D., Shahar, E., Cooper, L.S., Aleksic, N., Nieto, F.J., Rasmussen, M.L., Wu, K.K. Prospective study of markers of hemostatic function with risk of ischemic stroke. Circulation, 100: 736-742, 1999 .
43. Salomaa, V., Matei, C., Aleksic, N., Sansores, L., Folsom, A.R., Juneja, H., Chambless, L.E., Wu, K.K. Soluble thrombomodulin as a predictor of incident coronary heart disease: The ARIC Study. Lancet, 353: 1729-1734, 1999.
44. Xu, X-M., Sansores-Garcia, L., Chen, X-M., Matijevic-Aleksic, N., Du, M., Wu, K.K. Suppression of inducible cyclooxygenase-2 gene transcription by aspirin and sodium salicylate. Proc. Natl. Acad. Sci. USA, 96: 5292-5297, 1999.
45. Godbey, W.T., Wu, K.K., Mikos, A.G. Tracking the intracellular path of poly (ethylenimine)/DNA complexes for gene delivery. Proc. Natl. Acad. Sci. USA, 96: 5177-5181, 1999.
46. Godbey, W.T., Wu, K.K., Mikos, A.G. Size matters: Molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle. J. Biomed. Mat. Res., 45: 268-275, 1999.
47. Chen, P-F., Berka, V., Tsai, A-L. and Wu, K.K. Effects of D369 and R372 mutations on heme environment and function in human endothelial nitric oxide synthase. J. Biol. Chem., 273: 34164-34170, 1998.
48. Du, M., Sansores-Garcia, L., Zu, Z. and Wu, K.K. Cloning and expression analysis of a novel salicylate suppressible gene, Hs-CUL-3, a member of Cullin/Cdc53 family. J. Biol. Chem., 273: 24289-24292, 1998.
49. Cieslik, K., Zembowicz, A., Tang, J_L. and Wu, K.K. Transcriptional regulation of endothelial nitric oxide synthase by lysophosphatidylcholine. J. Biol. Chem., 273: 14885-14890, 1998.
50. Chen, P-F., Tsai, A-L., Berka, V., and Wu, K.K. Mutation of Glu-361 in human endothelial nitric oxide synthase selectively abolishes L-arginine binding without perturbing the behavior of heme and other redox centers. J. Biol. Chem., 272: 6114-6118, 1997.
51. Xu, X-M., Tang, J-L., Chen, X., Wang, L-H., Wu, K.K. Involvement of two Sp1 elements in basal endothelial prostaglandin H synthase-1 promoter activity. J. Biol. Chem., 272: 6943-6950, 1997.
52. Shyue, S-K., Ruan, K-H., Wang, L-H., and Wu, K.K. Prostacyclin synthase active sites: identification by molecular modeling-guided site-directed mutagenesis. J. Biol. Chem., 272: 3657-3662, 1997.
53. Tazawa, R., Green, E.D., Ohashi, K., Wu, K.K., and Wang, L-H. Characterization of the complete genomic structure of human thromboxane synthase gene and functional analysis of its promoter. Arch. Biochem. and Biophys., 334, 2: 349-356, 1996.
54. Wang, L.-H., Matijevic-Aleksic, N., Hsu, P.-Y., Ruan, K.-H., Wu, K.K., and Kulmacz, R.J.. Identification of thromboxane A2 synthase active site residues by molecular modeling-guided site-directed mutagenesis. J. Biol. Chem., 271: 19970-19975, 1996.
55. Chen, P.-F., Tsai, A.-L., Vladimir, B., and Wu, K.K. Endothelial nitric-oxide synthase. Evidence for bidomain structure and successful reconstitution of catalytic activity from two separate domains generated by a baculovirus expression system. J. Biol. Chem., 271: 14631-14635, 1996.
56. Zoldhelyi, P., McNatt, J., Xu, X-M., Loose-Mitchell, D., Meidell, R.S., Clubb, F.J., Buja, L.M., Willerson, J.T., Wu, K.K. Prevention of arterial thrombosis by adenovirus-mediated transfer of cyclooxygenase gene. Circulation, 93: 10-17, 1996.
57. Shahar, E., Folsom, A.R., Salomaa, V.V., Stinson, V.L., McGovern, P.G., Shimakawa, T., Chambless, L.E., Wu, K.K. Relation of hormone-replacement therapy to measures of plasma fibrinolytic activity. Circulation, 93: 1970-1975, 1996.
58. Chen, P-F., Tsai, A-L., Wu, K.K. Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity. Biochem. Biophys. Res. Commu., 215: 1119-1129, 1995.
59. Tang, J-L., Zembowicz, A., Xu, X-M., and Wu, K.K. Role of Sp1 in transcriptional activation of human nitric oxide synthase type III gene. Biochem. Biophys. Res. Commu., 213: 673-680, 1995.
60. Zembowicz, A., Jones, S.L., and Wu, K.K. Induction of cyclooxygenase-2 in human umbilical vein endothelial cells by lysophosphatidylcholine. J. Clin. Invest., 96: 1688-1692, 1995.
61. Zembowicz, A., Tang, J-L., and Wu, K.K. Transcriptional induction of endothelial nitric oxide synthase type-III by lysophosphatidylcholine. J. Biol. Chem., 270: 17006-17010, 1995.
62. Salomaa, V., Stinson, V., Kark, J.D., Folsom, A.R., Davis, C.E., Wu, K.K. Association of fibrinolytic parameters with early atherosclerosis. The ARIC Study. Atherosclerosis Risk in Communities Study. Circulation, 91: 284-290, 1995.
63. Chen, P-F, Tsai, A-L and Wu, K.K. Cysteine 184 of endothelial nitric oxide synthase is involved in heme coordination and catalytic activity. J. Biol. Chem., 269: 25062-25066, 1994.
64. Sanduja, S.K., Tsai, A-L, Matijevic-Aleksic, N. and Wu, K.K. Kinetics of prostacyclin synthesis in PGHS-1-overexpressed endothelial cell. Am. J. Physiol., 267: C1459-C1466, 1994.
65. Pereira, B., Wu, K.K. and Wang, L-H. Molecular cloning and characterization of bovine prostacyclin synthase. Biochem. Biophys. Res. Comm., 203: 59-66, 1994.
66. Tazawa, R., Xu, X-M, Wu, K.K. and Wang L-H. Characterization of the genomic structure, chromosomal location and promoter of human prostaglandin H synthase-2 gene. Biochem. Biophys. Res. Comm., 203: 190-199, 1994.
67. Ruan, K-H, Li, P., Kulmacz, R.J. and Wu, K.K. Characterization of the structure and membrane interaction of NH2-terminal domain of thromboxane A2 synthase. J. Biol. Chem., 269: 20938-20942, 1994.
68. Ruan, K-H, Wang, L-H, Wu, K.K. and Kulmacz, R.J. Amino-terminal topology of thromboxane synthase in the endoplasmic reticulum. J. Biol. Chem., 268: 19483-19490, 1993.
69. Xu, X-M, Ohashi, K., Sanduja, S.K., Ruan, K-H, Wang, L-H and Wu, K.K. Enhanced prostacyclin synthesis in endothelial cells by retrovirus-mediated transfer of prostaglandin H synthase cDNA. J. Clin. Invest., 91: 1843-1849, 1993.
70. Wang, L-H, Hajibeigi, A., Xu, X-M, Loose-Mitchell, D. and Wu, K.K. Characterization of the promoter of human prostaglandin H synthase-1 gene. Biochem. Biophys. Res. Comm., 190: 406-411, 1993.
71. Pereira, B., Wu, K.K. and Wang, L-H. Bovine prostacyclin synthase: purification and isolation of partial cDNA. Biochem. Biophys. Res. Comm., 197: 1041-1048, 1993.
72. Ohashi, K., Ruan, K-H, Kulmacz, R.J., Wu, K.K. and Wang, L-H. Primary structure of human thromboxane synthase determined from the cDNA sequence. J. Biol. Chem., 267: 789-793, 1992.
73. Wu, K.K., Sanduja, R., Tsai, Ah-lim, and Loose-Mitchell, D.: Aspirin inhibits the de novo synthesis and the mRNA level of prostaglandin H synthase in cultured endothelial cells. Proc. Natl. Acad. Sci. USA, 88: 2384-2387, 1991.

Selected Invited Review Articles and Book Chapters (from 1988)

01. Wu, K.K. Analysis of Protein-DNA binding by Streptavidin-Agarose Pulldown. In: Methods in Molecular Biology, vol. 338: Gene Mapping, Discovery, and Expression: Methods and Protocols. M. Bina, Ed., Humana Press, Totowa, New Jersey, pp. 281-290, 2006.
02. Wu, K.K., Liou, J.Y. Cellular and molecular biology of prostacyclin synthase. 50th Anniversary of Oxygenases Special Issue Inveited Review. Biochem Biophys Res Commun., 338: 45-52, 2005.
03. Wu, K.K., Liou, J.Y., Cieslik, K. Transcriptional Control of COX-2 via C/EBPbeta. Arterioscler. Thromb. Vasc. Biol. 25:679-685, 2005.
04. Wu, K.K., Matijevic-Aleksic, N. Molecular aspects of thrombosis and antithrombotic drugs. Crit. Rev. Clin. Lab Sci. 42:249-277, 2005.
05. Wu, K.K. Novel mechanisms of aspirin pharmacologic actions: a model for studying herbal natural products. Thromb. Res. 117:61-67, 2005.
06. Wu, K.K., Willerson, J.T. Monitoring platelet function in glycoprotein IIb-IIIa inhibitor therapy. Circulation, Editorial, 103:2528-2530, 2001.
07. Wu, K.K. Aspirin and salicylate: an old remedy with a new twist. Circulation, Editorial, 102: 2022-2023, 2000.
08. Thiagarajan, P., and Wu, K.K. Mechanisms of Antithrombotic Drugs. In: Advances in Pharmacol., 46: 297-324, 1999.
09. Wu, K.K. Nitric Oxide Synthase Gene Regulation. In: The Pathophysiology and Clinical Applications of Nitric Oxide. G. Rubanyi, Ed., Harwood Academic Publishers, Amsterdam, The Netherlands, pp. 35-45, 1999.
10. Wu, K.K. Cyclooxygenase-2 induction in congestive heart failure: friend or foe? Circulation, Editorial, 98: 95-6, 1998.
11. Wickline, S., Wu, K., et al. “NHLBI/FDA conference on thrombosis and infections with cardiovascular devices. J. Biomed. Mat. Res., 42: 341-346, 1998.
12. Wu, K.K. “Cyclooxygenase gene expression and regulation.” In: Eicosanoids, Aspirin and Asthma, C. Lenfant, A. Szczeklik, R.J. Gryglewski and J.R. Vane, Eds., Marcel Dekker, Inc., New York, New York, pp. 129-144, 1998.
13. Wu, K.K. Biochemical Pharmacology of Nonsteroidal Anti-inflammatory Drugs. Biochem. Pharmacol., 55: 543-547, 1998.
14. Wu, K.K. Regulation and augmentation of prostacyclin and nitric oxide synthesis. J. Formosan Med. Assoc., 9: 661-666, 1996.
15. Wu, K.K., and Thiagarajan, P. Endothelial cell function in hemostasis and thrombosis. Annu. Rev. Med., 47: 315-331, 1996.
16. Wu, K.K. Inducible cyclooxygenase and nitric oxide synthase. Adv. Pharmacol., 33: 179-207, 1995.
17. Wu, K.K. Molecular Regulation and Augmentation of Prostacyclin Biosynthesis. Mediators in the Cardiovascular System: Regional Ischemia. Agents and Actions Supplements. K. Schror and C.R. Pace-Asciak, Eds. Birkhauser Verlag, Basel, Boston, Berlin, Vol. 45: 11-17, 1994.
18. D'Souza, D., Phillips, M., Hellums, J.D. and Wu, K.K. Platelet activation and arterial thrombosis. Lancet. 344: 991-995, 1994.
19. Wu, K.K. and Stinson, V. Laboratory evaluation of arterial thrombosis. Current Opinion in Hematology, 296-300, 1993.
20. Wu, K.K. Endothelial cell function in hemostasis and thrombosis. In: Endothelium in Health and Disease, S. Chien, Ed. Plenum Publishing, pp. 127-134, 1988.

Books

01. Wu, K.K. (editor): Pathophysiology and Management of Thromboembolic Disorders. PSG Publishing Company, Inc., Massachusetts, 1984.
02. Wu, K.K., and Rossi, E.C. (co-editors): Prostaglandins in Cardiovascular and Thrombotic Disorders. Year Book Medical Publishers, 1981.