Vice President's Office

Vice President I.K. Ho, Ph.D.

Patents

Publications

Books Edited

Selected Original Articles in Referenced Journals (from 2000)

  1. Sun, T.-T., Paul, I.A. and Ho, I.K.Motor functions but not learning and memory are impaired upon repeated exposure to sub-lethal doses of methyl parathion.J. Biomed. Sci. 13: 515-523, 2006.
  2. Kim, S.-Y., Chudapongse, N., Lee, S.M., Levin, M.C., Oh, J.T., Park H.J. and Ho, I.K.Proteomic analysis of phosphotyrosyl proteins in morphine-dependent rat brains.Molec. Brain Res. 133: 58-70, 2005.
  3. Oh, S., Chang, C.-Y., Baker, R.C. and Ho, I.K.Phorbol ester differentiates the levels of [3H]MK-801 binding in rat lines selected for differential sensitivity to the hypnotic effects of ethanol.Neurochem. Res. 30: 161-169, 2005.
  4. Tanaka, S., Fan, L.-W., Tien, L.-T., Park, Y., Liu-Chen, L.-Y., Rockhold, R.W. and Ho, I.K.Butorphanol dependence increases hippocampal κ-opioid receptor gene expression.J. Neurosci. Res. 82: 255-263, 2005.
  5. Chiu, C.-T., Ma, T. and Ho, I.K.Attenuation of methamphetamine-induced behavioral sensitization in mice by systemic administration of nalrexone.Brain Res. Bull. 67: 100-109, 2005.
  6. Tien, L.-T., Fan, L.-W., Ma, T., Loh, H.H. and Ho, I.K.Roles of m-opioid receptors in development of tolerance to diisopropylfluorophosphate (DFP).J. Toxicol. Sci. 30: 43-59, 2005.
  7. Commiskey, S., Fan, L.-W., Ho, I.K. and Rockhold, R.W.Butorphanol: Effects of a prototypical agonist-antagonist analgesic on κ-opioid receptors.J. Pharmacol. Sci. 98: 109-116, 2005.
  8. Ho, I.K., Fan, L.-W., Kim, S.-Y., Ma, T. and Rockhold, R.W.Neurochemical alterations in physical dependence on butorphanol.J. Appl. Pharmacol. 12: 198-201, 2004.
  9. Zhu, H., Zhou, W., Li, X.R., Ma, T., Ho, I.K. and Rockhold, R.W.Methyl parathion increases neuronal activities in the rat locus coeruleus.J. Biomed. Sci. 11: 732-738, 2004.
  10. Yoo, J.-H., Lee, S.-Y., Loh, H.H., Ho, I.K. and Jang, C.-G.Altered emotional behaviors and the expression of 5-HT1A and M1 muscarinic receptors in m-opioid receptor knockout mice.Synapse 54: 72-82, 2004.
  11. Kim, S.-Y., Chudapongse, N., Lee, S.-M., Levin, M.C., Oh, J.-T., Park, H.-J. and Ho, I.K.Proteomic analysis of phosphotyrosyl proteins in the rat brain: Effect of butorphanol dependence.J. Neurosci. Res. 77: 867-877, 2004.
  12. Tien, L.T., Fan, L.W., Ma, T., Loh, H.H. and Ho, I.K.Increased diisopropylfluorophosphate (DFP)-induced toxicity in m-opioid receptor knockout mice.J. Neurosci. Res. 78: 259-267, 2004.
  13. Yoo, J.-H., Lee, S.-Y., Loh, H.H., Ho, I.K. and Jang, C-G.Loss of nicotine-induced behavioral sensitization in μ-opioid receptor knockout mice.Synapse 51: 219-223, 2004.
  14. Tien, L.T., Fan, L.W., Sogawa, C., Ma, T., Loh, H.H. and Ho, I.K.Changes in acetylcholinesterase activity and muscarinic receptor bindings in μ-opioid receptor knockout mice.Mol. BrainRes. 126: 38-44, 2004.
  15. Sun, T., Ma, T. and Ho, I.K.Differential modulation of muscarinic receptors in the rat brain by repeated exposure to methyl parathion.J. Toxicol. Sci. 28: 427-438, 2003.
  16. Chudapongse, N., Kim, S., Kramer, R.E. and Ho, I.K.Nonspecific effects of U-50,488H, a κ-opioid agonist, on dopamine uptake and release in PC12 cells.J. Pharmacol. Sci. 93: 372-375, 2003.
  17. Chudapongse, N., Kim, S., Sasaki, K.,. Kramer, R.E and Ho, I. K..Nonopioid receptor‑mediated effects of U‑50,488H on [Ca2+]i and extracellular dopamine in PC12 cells.J Neurosci. Res. 74: 598-604, 2003.
  18. Fan, L.-W., Tien, L.-T., Tanaka, S., Ma, T., Chudapongse, N., Sinchaisuk, S., Rockhold, R.W. and Ho, I.K.Changes in the brain κ-opioid receptor levels of rats in withdrawal from physical dependence upon butorphanol.Neurosci. 121: 1063-1074, 2003.
  19. Tien, L.-T., Park, Y., Fan, L.-W., Ma, T. Loh, H.H. and Ho, I.K.Increased dopamine D2 receptor binding and enhanced apomorphine-induced locomotor activity in μ-opioid receptor knockout mice.Brain Res. Bull. 61: 109-115, 2003.
  20. Park, Y., Jang, C.-G., Yang, K.-H., Loh, H. H., Ma. T. and Ho, I. K.Regional specific increases of [3H]AMPA binding and mRNA expression of AMPA receptors in the brain of μ-opioid receptor knockout mice.Mol. Brain Res. 113: 116-123, 2003.
  21. Fan, L.-W., Tien, L.-T., Tanaka, S., Sasaki, K., Park, Y., Ma, T., Rockhold, R.W. and Ho, I.K.Enhanced binding of nor-binaltorphimine to κ-opioid receptors in rats dependent upon butorphanol.J. Neurosci. Res. 72: 781-789, 2003.
  22. Ma, T., Kramer, R.E., Baker, R.C., Fan, L.-W. and Ho, I.K.Effects of chronic dermal exposure to nonlethal doses of methyl parathion on brain regional acetylcholinesterase and muscarinic cholinergic receptors in female rats.J. Neurosci. Res. 71: 138-145, 2003.
  23. Fan, L.-W., Rockhold. R.W. and Ho, I.K.κ-Opioid receptors in physical dependence upon butorphanol.J. Med. Sci. 23: 1-18, 2003.
  24. Zhu, H., Ho, I.K., Kramer, R.K., Baker, R.C. and Rockhold, R.W.Methyl parathion masks withdrawal from physical dependence on morphine.Intl. J. Molecular Sci. 3: 1073-1081, 2002.
  25. Sinchaisuk, S., Ho, I. K. and Rockhold, R. W.Focal κ-opioid receptor-mediated dependence and withdrawal in the nucleus paragigantocellularis.Pharmacol. Biochem. Behav. 74: 241-252, 2002.
  26. Fan, L.-W., Tanaka, S., Park, Y., Sasaki, K., Ma, T., Tien, L.-T., Rockhold, R.W. and Ho, I.K.Butorphanol dependence and withdrawal decrease hippocampal κ2-opioid receptor binding.Brain Res. 958: 277-290, 2002.
  27. Kramer, R. E. and Ho, I. K.Pharmacokinetics and pharmacodynamics of methyl parathion.Chin. Med. J. 65: 187-199, 2002.
  28. Fan, L.-W., Tanaka, S., Tein, L.-T., Ma, T., Rockhold, R.W. and Ho, I. K.Withdrawal from dependence upon butorphanol uniquely increases κ1-opioid receptor binding in the rat brain.Brain Res. Bull. 58: 149-160, 2002.
  29. Sasaki, K., Fan, L.-W., Tien, L.-T., Ma, T., Loh, H. H. and Ho, I. K.The interaction of morphine and GABAergic systems in anxiolytic behavior: using mu-opioid receptor knockout mice.Brain Res. Bull. 57: 689-694, 2002.
  30. Zhu, H., Rockhold, R. W., Baker, R. C., Kramer, R. E. and Ho, I. K.Effects of single or repeated dermal exposure to methyl parathion on behavior and blood cholinesterase activity in rats.J. Biomed. Sci. 8: 467-474, 2001.
  31. Oh, S., Kim, Y.H., Hann, H. J., Lee, H. L., Choi, H. S., Kim, H. S. and Ho, I. K.Modulation of the levels of NMDA receptor subunit mRNA and the bindings of [3H’MK801 in rat brain by chronic infusion of subtoxic dose of MK-801.Neurochem. Res. 26: 559-565, 2001.
  32. Chen, H., Ma, T. and Ho, I. K.Effects of developmental lead exposure on inhibitory avoidance learning and glutamate receptors in rats.Environ. Toxicol. Pharmacol. 9: 185-191, 2001.
  33. Tokuyama, S., Zhu, H., Oh, S. Ho, I. K. and Yamamoto, T.Further evidence for a role of NMDA receptors in the locus coeruleus in the expression of withdrawal syndrome from opioids.Neurochem. 39: 103-109, 2001.
  34. Ma, T., Cai, Z., Wellman, S. and Ho, I. K..A quantitative histochemistry technique for measuring regional distribution of acetylcholinesterase in the brain using digital scanning densitometry.Analyt. Biochem. 296: 18-28, 2001.
  35. Jang, C.-G., Lee, S.-Y., Park, Y., Ma, T., Loh, H. H. and Ho, I. K.Differential effects of morphine, DPDPE, and U-50488 on apomorphine-induced climbing behavior in μ-opioid receptor knockout mice.Molec. Brain Res. 94: 197-199, 2001.
  36. Jang, C.-G., Lee, S.-Y., Loh, H. H. and Ho, I. K..Lack of μ-opioid receptor gene leads to an increase in the NMDA receptor subunit mRNA expression and NMDA-induced convulsion.Molec. Brain Res. 94: 105-111, 2001.
  37. Kimura, T., Ho, I. K. and Yamamoto, T.Uridine receptor: Discovery and its involvement in the sleep mechanism.Sleep 24: 251-260, 2001.
  38. Park, Y., Ho, I. K., Fan, L.-W., Loh, H. H, and Ko, K. H..Region specific increase of dopamine receptor D1/D2 mRNA expression in the brain of μ-opioid receptor knockout mice. Brain Res. 894: 311-315, 2001.
  39. Park, Y., Jang, C.-G., Tanaka, S., Ma, T., Loh, H. H., Ho, I. K. and Ko, K. H.Effects of morphine on pentobarbital-induced responses in μ-opioid receptor knockout mice. Brain Res. Bull. 54: 527-531, 2001.
  40. Kimura, T. Miki, M., Ikeda, M., Ynemoto, S., Watanabe, K., Kondo, S., Ho, I. K. and Yamamoto, I.Possible existence of a novel receptor for uridine analogues in the central nervous system using two isomers, N3-(S)-(+) and N3-(R)-(-)-α-hydroxy-β-phenethyluridines.Biol. Pharm. Bull. 24(6): 727-731, 2001.
  41. Kimura, T., Yao, S., Watanabe, K., Kondo, S., Ho, I. K., and Yamamoto, I.Hypnotic action of N3-substituted abrabinofuranosyluracils on mice.Chem. Pharm. Bull. 49: 111-113, 2001.
  42. Kimura, T., Miki, M., Watanabe, K., Kondo, S., Ho, I. K. and Yamamoto, I.Metabolism of a novel hypnotic, N3-phenacyluridine, and hypnotic and sedative activities of its enantiomer metabolites in mice.Xenobiotica, 30: 643-653, 2000.
  43. Jang, C.-G., Park, Y., Tanaka, S., Ma, T., Loh, H. H. and Ho, I. K.Involvement of μ-opioid receptors in potentiation of apomorphine-induced climbing behavior by morphine: studies using μ-opioid receptor gene knockout mice.Mol. Brain Res. 78: 204-206, 2000.
  44. Park, Y., Ma, T., Tanaka, S., Jang, C.-G., Loh, H. H., Ko, K. H. and Ho, I. K.Comparison of G-protein activation in the brain by μ-, δ-, and κ-opioid receptor agonists in μ-opioid receptor knockout mice.Brain Res. Bull. 52: 297-302, 2000.
  45. Jang, C.-G., Rockhold, R. W. and Ho, I. K.An autoradiographic study of [3H]AMPA receptor binding and in situ hybridization of AMPA sensitive glutamate receptor A (GluR-A) subunits following morphine withdrawal in the rat brain.Brain Res. Bull. 52: 217-221, 2000.
  46. Park, Y., Jang, C.-G., Ho, I. K. and Ko, K. H.Kappa-opioid agonist stimulated regional distribution of [35S]GTPgS binding in butorphanol continuously infused rat.Brain Res. Bull. 52: 17-20, 2000.
  47. Jang, C.-G. and Ho, I. K.N-methyl D-aspartate receptor NR1 subunit mRNA level was decreased in rat brain during pentobarbital withdrawal.Neurosci. Lett. 282: 129-132, 2000.
  48. Tokuyama, S., Ho, I. K. and Yamamoto, T.A protein kinase inhibitor, H-7, blocks naloxone-precipitated changes in dopamine and its metabolites in the brains of opioid-dependent rats.Brain Res. Bull. 52: 363-369, 2000.
  49. Rockhold, R. W., Zhu, H., Liu, N. and Ho, I. K.The nucleus paragigantocellularis and opioid withdrawal-like behavior.J. Biomed. Sci.7:270-276, 2000.