National Institute of Cancer Research

Taiwan Cooperative Oncology Group, TCOG

Introduction | Background | Accomplishments | Clinical Protocols | Future Direction | Structure | Cooperative Hospitals | Historical Events | Members

Finished Clinical Protocols

  1. T1188 - Phase II Study of Weekly CAF Combination Chemo-therapy for Advanced Breast Cancer
    • Time: Oct. 1988 – Dec. 9, 1994
    • Patient Accrual: 107
    • Publication: "Weekly CAF Chemotherapy for Advanced Breast Cancer Patients". WS Hwang, CA Hsiung, WS Ko. Oncology 1997; 54:293-297.
  2. T1488 - A Prospective Study of Intermediate / High Grade Non-Hodgkin's Lymphoma-direct Comparison of T and B Cell Lymphoma in Taiwan by Using Combination Chemotherapy CHOP
    • Time: Sep. 1988 – Dec. 9, 1994
    • Patient Accrual:213
  3. T1788 - Phase II Trial of VP16-Isophosphamide / Mesna Cis-platin (VIP) in Advanced Soft Tissue Sarcoma
    • Time: Jul. 1988 – Dec. 3, 1994
    • Patient Accrual: 90
  4. T1592 - Evaluation of Dose Optimization of Carboplatin in Treatment of Chinese Patients with Small Cell Lung Cancer
    • Time: Feb. 28, 1992 – May 1, 1995
    • Patient Accrual: 40
  5. T1394 - A Phase III Study of Radiotherapy with or Without Adjuvant Chemotherapy in Advanced Stage Nasopharyngeal Carcinoma Patients
    • PIs are Dr. Kuang-Yao Chen and Dr. Kwan-Hwa Chi of Nasopharyngeal Carcinoma Committee.
    • Time: Nov. 1994 – Jul. 15, 1999
    • Patient Accrual: 158
    • Publication: A Phase III Study of Adjuvant Chemotherapy in Advanced Nasopharyngeal Carcinoma Patients". KH Chi, YC Chang, WY Guo. Int. J. Radiation Oncology Biol. Phys., Vol. 52, No. 5. pp. 1238-1244, 2002.
  6. T1495 - A Comparative Study of Steroid-containing versus Steroid-free Chemotherapy for Non-Hodgkin's Lymphoma in Hepatitis B Virus Carriers
    • PIs are Dr. Ann-Lii Cheng and Dr Pei-Jer Chen of the Lymphoma Committee.
    • Time: Nov. 1995 – May 10, 2000
    • Patient Accrual: 50
    • Publication: "Steroid-Free Chemotherapy Decreases Risk of Hepatitis B Virus (HBV) Reactivation in HBV-Carriers With Lymphoma". AL Cheng, CA Hsiung, IJ Su, Hepatology. Vol. 37, No. 6, pp. 1320-1328, 2003.
  7. T1296 - Eradication of Helicobacter Pylori in the Management of Stage IE & IIE-1 Primary Low-grade B Cell Lymphoma of Mucosa-associated Lymphoid Tissue Type (MALToma) of the Stomach
    • PI is Dr. Li-Tzong Chen of the Gastric MALToma Disease Committee.
    • Time: Mar. 2, 1996 – Apr. 1, 1999
    • Patient Accrual:41
    • Publication:
      • "Prospective Study of Helicobacter Pylori Eradication Therapy in Stage I(E) High-grade Mucosa-associated Lymphoid Tissue Lymphoma of the Stomach". LT Chen, JT Lin, RY Shyu. J Clin Oncol. 2001 Nov 15; 19(22):4245-51.
      • "Long-Term Results of Anti-Helicobacter pylori Therapy in Early-Stage Gastric High-Grade Transformed MALT Lymphoma". LT Chen, JT Lin, J Tai. Journal of the National Cancer Institute, Vol. 97, No. 18, pp. 1345-1353, 2005.
  8. Gastric Adenocercinoma Study in Surgery and Pathology
    • PI is Dr. Chew-Wun Wu of the Gastric Cancer Committee.
    • Time: Jun. 1998 – Dec. 31, 2000
    • Patient Accrual: 1303
    • The PI is now preparing the final report.
  9. T1297 - Phase III Randomized Trial Comparing Adjuvant Recombinant Interferon-α versus Conservative Treatment in Postoperative Hepatocellular Carcinoma
    • PIs are Dr. Li-Tzong Chen and Dr. Pei-Jer Chen of the Hepatocellular Carcinoma Postoperative Adjuvant Therapy Committee.
    • Time: Oct. 1, 1997 – Apr. 30, 2003
    • Patient Accrual: 268
    • The PI is now preparing the final report.
  10. T1899 - A Multi-center Survey of HPV in Cervical Intraepithelial Neoplasia (CIN) with Longitudinal Follow-up of LSIL Cases
    • PIs are Dr. Tang-Yaun Chu, Dr. Chi-An Chen and Tzer-Ming Chen of Gynecologic Oncology Committee. This project intended to recruit 1000 patients.
    • Time: Aug. 18, 1997 – Feb. 10, 2004
    • Patient Accrual: 1332
    • Publication:
      • "Epidemiologic Correlates of Cervical Human Papillomavirus Prevalence in Women With Abnormal Pap Smear Tests: a Taiwan Cooperative Oncology Group (TCOG) Study". TY Chu, CA Sun, CA Hsiung. Journal of Medical Virology. 77:273-281, 2005.
      • "The Distribution and Differential Risks of Human Papillomavirus Genotypes in Cervical Preinvasive Lesions: a Taiwan Cooperative Oncologic Group (TCOG) Study". CA Chen, CY Lin, HH Chou. International Journal of Gynecological Cancer, 16(5): 1801-8, 2006.
  11. T2201 - Postoperative Adjuvant Chemoradiotherapy for Patients with Stage III & IVA Adenocarcinoma of Stomach -- A Phase III Randomized Clinical Trial
    • PI is Dr. Jang-Yang Chang of the Gastric Cancer Committee. This project intended to recruit 264 patients.
    • Time: Apr. 1, 2001 – Mar. 9, 2004
    • Patient Accrual: 14
    • The study was early terminated.
  12. T1E01 - Adjuvant Therapy After Radical Hysterectomy for Patients Who Have Stage Ib-IIa Cervical Carcinoma with Pelvic Lymph Node Metastases
    • PI is Dr. Chyong-Huey Lai of the Gynecologic Oncology Committee. This project intended to recruit 260 patients.
    • Time: Feb. 1, 2002 – Mar. 22, 2004
    • Patient Accrual: 4
    • The study was early terminated.
  13. T1802 - An Open, Non-comparative Trial to Assess the Efficacy and Safety of Oral Thalidomide (THADO) in Patients with Hormone-refractory Prostate Cancer - A Phase II Clinical Trial
    • PI is Dr. Ruey-Kuen Hsien of the Chemotherapy Committee. This project intended to recruit 70 patients.
    • Time: Nov. 1, 2002 – Apr. 14, 2004
    • Patient Accrual: 30
    • The PI is now preparing the final report.
  14. T3202 - Weekly Gemcitabine plus High-dose 5-Fluorouracil/ Leucovorin in the Treatment of Advanced or Metastatic Carcinoma of the Biliary Tract - A Phase II Clinical Trial
    • PI is Dr. Chiun Hsu of the Chemotherapy Committee. This project intended to recruit 41 patients.
    • Time: July 1, 2002 – Aug. 2, 2004
    • Patient Accrual: 50
    • The PI is now preparing the final report.
  15. T2399 - Phase III Study of Post-Operative Adjuvant Concurrent Chemoradiotherapy for High-Risk Oral Cavity Squamous Cell Carcinoma Patients
    • PI is Dr. Mow-Ming Hsu and Dr. Ruey-Long Hong of Head & Neck Cancer Committee. This project intended to recruit 480 patients.
    • Time: Aug. 1999 – Sept. 13, 2004
    • Patient Accrual: 161
    • The PI is now preparing the final report.
  16. T1401 - A Randomized Study of Prophylaxis or Therapeutic Effects of Lamivudine Against Hepatitis B Reactivation in Non-Hodgkin's Lymphoma Patients Carrying Hepatitis B Surface Antigen and Undergoing Lymphoma Chemotherapy
    • PIs are Dr. Ann-Lii Cheng and Dr Pei-Jer Chen of the Lymphoma Committee. This project intended to recruit 90 patients.
    • Time: Oct. 1, 2001 – Mar. 11, 2005
    • Patient Accrual: 52
    • The PI is now preparing the final report.
  17. T1399 - Phase III Placebo-Controlled Chemoprevention Study of Oral Cavity Squamous Cell Carcinoma Patients
    • PIs are Dr. Mow-Ming Hsu and Dr. Ruey-Long Hong of Head & Neck Cancer Committee. This project intended to recruit 342 patients.
    • Time: Apr. 1999 – Jun. 2005
    • Patient Accrual: 342
    • The PI is now preparing the final report.
  18. T2202 - Double-blind, Placebo-controlled, Randomized Phase III Trail of Oral Thalidomide in Advanced Hepatocellular Carcinoma with Poor Liver Reserve.
    • PI is Dr. Li-Tzong Chen of the Chemotherapy Committee. This project intended to recruit 230 patients.
    • Time: Feb. 2003 – Jul. 2007
    • Patient Accrual: 116
    • The PI is now preparing the final report.
  19. Integrated HPV, E2/E6 Ratio and Viral Loads in Relation to the Outcomes of Low-grade Squamous Intraepithelial Lesion of Uterine Cervix. (Ancillary laboratory research from TCOG T1899 study)
    • PI is Dr. Chih-ming Ho of Gynecologic Oncology Committee.
    • Publication: "Human Papillomaviral Load Changes in Low-grade Squamous Intraepithelial Lesions of the Uterine Cervix". CM Ho, WF Cheng, TY Chu. British Journal of Cancer, 95(10):1384-9, 2006.
  20. Methylation of HPV Genome and SNP of Immune Response Genes in Relation to the Outcomes of Squamous Intraepithelial Lesion of Uterine Cervix. (Ancillary laboratory research from TCOG T1899 study)
    • PI is Dr. Tang-Yuan Chu of Gynecologic Oncology Committee.
  21. Heritable Colorectal Cancer Registry.
    • PI is Dr. Reiping Tang of the Colorectal Cancer Committee. This project intended to recruit 800 patients.
    • This project intended to recruit 800 subjects (patients and their family).
    • Time: May 1, 2002 – Dec. 31, 2006
    • Patient Accrual: patients 99, family 718
  22. T1202 - Prospective Phase II Randomized Trial of Postoperative Adjuvant Chemo-therapy in Patients with High Risk Colon Cancer
    • PI is Dr. Tsai-Shen Yang of the Colorectal Cancer Committee. This project intended to recruit 162 patients.
    • This project intended to recruit 162 patients.
    • Time: Apr. 1, 2002 – Dec. 2007
    • Patient Accrual:162

On-Going Protocols

  1. T1303 - A Multicenter Phase III Trial Comparing Induction Chemotherapy Followed by Concurrent Chemoradiotherapy versus Concurrent Chemoradiotherapy Alone in Stage IV Nasopharyngeal Carcinoma (NPC)
    • PIs are Dr. Ruey-Long Hong, Dr. Mow-Ming Hsu and Dr. Cheng-Hsu Wang of Nasopharyngeal Carcinoma Committee. This project intended to recruit 480 patients.
    • Time: Aug. 1, 2003 – now
    • Patient Accrual: 418 (up to July 2008)
  2. T1204 - A Phase II Study of Induction Chemotherapy Followed by Concurrent Chemotherapy with Radiotherapy in Locally Advanced Pancreatic Cancer.
    • PIs are Dr. Hui-Ju Mandy Ch'ang and Dr. Li-Tzong Chen of the Pancreatic Disease Committee. This project intended to recruit 45 patients.
    • Time: Nov. 10, 2004 – now
    • Patient Accrual: 49 (up to July 2008)
  3. T1405 - A Phase II Study of Concurrent Chemoradiation for the Localized Nasal NK/T-cell Lymphoma
    • PI is Dr. Ming-Chih Chang of the Lymphoma Cancer Disease Committee.
    • Time: May 2006 – now
    • Patient Accrual: 21 (up to July  2008)
  4. T3206 - Multicentre, Prospective Study of First-line Antibiotic Therapy for Early-stage Low-grade and High-grade Gastric Mucosa-associated Lymphoid Tissue-type Lymphoma and Potential Predicting Factor for Treatment Outcome
    • PIs are Dr. Li-Tzong Chen and Dr. Jaw-Town, Lin of the MATLoma Disease Committee. This project intended to recruit 90 patients.
    • Time: Oct. 2006 – now
    • Patient Accrual: 11 (up to July 2008)
  5. T1406 - High-dose Methotrexate Plus Steroid Followed by Concurrent Whole Brain Chemoradiation with Temozolomide for Immunocompetent Patients with Primary Central Nervous System Lymphoma - A Phase II Study
    • PIs are Dr. Ching-Hung Lin and Dr. Ann-Lii Cheng of the Lymphoma Cancer Disease Committee. This project intended to recruit 25 patients.
    • Time: Nov. 2006 – now
    • Patient Accrual:1 (up to July 2008)
  6. T1706 - Multiple Centers, Prospective, Phase II Trial of Gemcitabine and Docetaxel Combination Chemotherapy in Patients with Locally Advanced/Metastatic Soft Tissue Sarcoma or Imatinib Mesylate Refractory Advanced/Metastatic Malignant Gastrointestinal Stromal Tumor.
    • PI is Dr. C. Hubert Chan of the Chemotherapy Committee. This project intended to recruit 88 patients.
    • Time: Dec. 2006 – now
    • Patient Accrual: 34 (up to June 2008)
  7. T1206 - Randomized Trial of Adjuvant Anti-viral Nucleoside (Lamivudine versus Adefovir) in Postoperative Low-risk HBV-related Hepatocellular Carcinoma.
    • PIs are Dr. Li-Tzong Chen and Dr. Pei-Jer Chen of the Hepatocellular Carcinoma Postoperative Adjuvant Therapy Committee. This project intended to recruit 309 patients.
    • Time: Apr. 2007 – now
    • Patient Accrual: 45 (up to July 2008)
  8. T1306 - A Phase II/III Randomized Study of Adjuvant Anti-Angiogenesis Therapy for Patients of High-Risk Oral Cavity Cancer.
    • PI is Dr. Ruey-Long Hong of Head & Neck Cancer Committee. This project intended to recruit 448 patients.
    • Time: May 2007 – now
    • Patient Accrual: 52 (up to July 2008)
  9. T2207－A Phase II Trial of Celecoxib with Preoperative Chemoradiation for Locally Advanced Rectal Cancer.
    • PI is Dr. Ling-Wei Wang of the Colorectal Cancer Committee. This project intended to recruit 48 patients.
    • Time: June 2008 – now
    • Patient Accrual: 1 (up to July 2008)